Targeting LDL Cholesterol With LNA
نویسندگان
چکیده
منابع مشابه
Targeting LDL Cholesterol With LNA
1RaNA Therapeutics, Cambridge, Massachusetts, USA Correspondence: Arthur M Krieg, RaNA Therapeutics, 25 First Street, Suite 303, Cambridge, Massachusetts 02141, USA. E-mail: [email protected] Cardiovascular disease is the number one cause of death in the industrialized world. Much of the morbidity and mortality from heart disease can be linked to elevated low-density lipoprotein (LDL) cholester...
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able amounts of radiolabeled dextran in the plasma protein fraction [15]. Consequently, we do not think this mechanism plays a substantial role in producing the lower than expected dextran concentrations seen in the present study. The dextran we used had a mean molecular mass of 70 000 Da. Thus, some quantity of lower-molecular-mass dextran could have leaked out of the vascular space and distri...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2012
ISSN: 2162-2531
DOI: 10.1038/mtna.2011.8